Two sample MR report

Telomere_length against ThalamNuclei lh volume CM

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0806161	0.1395541	0.5696300
Weighted median	23	0.0698571	0.0571112	0.2212631
Inverse variance weighted	23	0.0292342	0.0534828	0.5846472
Simple mode	23	0.0132750	0.0820866	0.8730025
Weighted mode	23	0.0328074	0.0645835	0.6165205

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.38871	21	0.0050177
Inverse variance weighted	41.70404	22	0.0067872

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031548	0.0078872	0.6932026

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012807	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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