Two sample MR report

Telomere_length against ThalamNuclei lh volume CL

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0480082	0.1389133	0.7330829
Weighted median	23	0.0327927	0.0549750	0.5508401
Inverse variance weighted	23	0.0441722	0.0530364	0.4049201
Simple mode	23	-0.0003397	0.0841663	0.9968157
Weighted mode	23	0.0177868	0.0623948	0.7782583

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.00883	21	0.0055930
Inverse variance weighted	41.01059	22	0.0082172

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002355	0.007851	0.9763508

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012817	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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