Two sample MR report

Telomere_length against ThalamNuclei lh volume AV

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0388439	0.1658764	0.8171182
Weighted median	23	0.0485604	0.0600822	0.4189561
Inverse variance weighted	23	0.0258062	0.0635988	0.6849154
Simple mode	23	0.0399529	0.0964540	0.6827259
Weighted mode	23	0.0046669	0.0721829	0.9490336

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	58.47502	21	2.17e-05
Inverse variance weighted	58.97423	22	3.17e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0039695	0.0093749	0.6762981

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017999	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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