Two sample MR report

Telomere_length against QC tfMRI-to-T1 linear alignment discrepancy

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0953949	0.1625506	0.5635524
Weighted median	23	0.0870494	0.0639482	0.1734352
Inverse variance weighted	23	0.1300210	0.0621631	0.0364735
Simple mode	23	0.1072026	0.1049888	0.3183114
Weighted mode	23	0.0773768	0.0652291	0.2481841

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.73859	21	0.0005450
Inverse variance weighted	48.86290	22	0.0008335

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021278	0.009194	0.8192178

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017748	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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