Two sample MR report

Telomere_length against QC tfMRI inverse tSNR

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2167826	0.1067012	0.0550313
Weighted median	23	0.1090427	0.0613149	0.0753374
Inverse variance weighted	23	0.0456273	0.0417120	0.2740142
Simple mode	23	0.1012118	0.1033798	0.3382101
Weighted mode	23	0.1066520	0.0724129	0.1549603

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.48146	21	0.7980417
Inverse variance weighted	18.51861	22	0.6748352

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0105178	0.0060352	0.096005

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005974	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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