Two sample MR report

Telomere_length against QC tfMRI head motion

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0882946	0.1106574	0.4338540
Weighted median	23	0.0352459	0.0622163	0.5710501
Inverse variance weighted	23	-0.0260350	0.0435134	0.5496254
Simple mode	23	-0.1431863	0.1141056	0.2226976
Weighted mode	23	0.0159291	0.0780868	0.8402352

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.58625	21	0.3664285
Inverse variance weighted	23.94146	22	0.3503055

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0070257	0.0062589	0.2743164

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007373	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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