Two sample MR report

Telomere_length against QC rfMRI-to-T1 linear alignment discrepancy

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0854549	0.1437921	0.5586639
Weighted median	23	0.0953853	0.0604087	0.1143358
Inverse variance weighted	23	0.1253886	0.0550292	0.0226920
Simple mode	23	0.0876947	0.0996307	0.3882665
Weighted mode	23	0.0718326	0.0626571	0.2639303

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.59455	21	0.0026376
Inverse variance weighted	43.78353	22	0.0037742

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024523	0.0081277	0.7658332

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016397	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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