Two sample MR report

Telomere_length against QC rfMRI inverse tSNR

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0571451	0.1223787	0.6453420
Weighted median	23	0.0116768	0.0566931	0.8368185
Inverse variance weighted	23	-0.0503639	0.0477354	0.2913966
Simple mode	23	-0.0584182	0.1069423	0.5903853
Weighted mode	23	0.0148685	0.0597308	0.8057274

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.57580	21	0.0645946
Inverse variance weighted	32.94545	22	0.0626452

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.006602	0.0069174	0.3507314

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010488	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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