Two sample MR report

Telomere_length against QC rfMRI head motion

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0661351	0.1274492	0.6092470
Weighted median	23	0.0233728	0.0553468	0.6728078
Inverse variance weighted	23	-0.0000684	0.0490376	0.9988870
Simple mode	23	0.0128053	0.0940983	0.8929925
Weighted mode	23	-0.0044130	0.0614307	0.9433809

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.24827	21	0.0340818
Inverse variance weighted	34.76768	22	0.0409650

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040655	0.007204	0.5784984

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010535	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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