Two sample MR report

Telomere_length against QC rfMRI cleaned inverse tSNR

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0381011	0.1273792	0.7677923
Weighted median	23	-0.0369792	0.0585963	0.5279853
Inverse variance weighted	23	-0.0267467	0.0489957	0.5851359
Simple mode	23	-0.0796103	0.0969113	0.4201890
Weighted mode	23	-0.0174279	0.0698553	0.8052994

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.20714	21	0.0344311
Inverse variance weighted	34.70544	22	0.0415786

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039822	0.0071999	0.5860423

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010658	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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