Two sample MR report

Telomere_length against QC dMRI-to-T1 linear alignment discrepancy

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1751834	0.1455177	0.2420374
Weighted median	23	0.0947127	0.0546831	0.0832686
Inverse variance weighted	23	0.1191318	0.0557959	0.0327500
Simple mode	23	0.0964404	0.0882485	0.2862922
Weighted mode	23	0.0914113	0.0599539	0.1415835

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.77465	21	0.0018538
Inverse variance weighted	45.14802	22	0.0025414

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034418	0.0082248	0.6798512

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016514	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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