Two sample MR report

Telomere_length against QC dMRI eddy outlier slices

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0020541	0.1089333	0.9851339
Weighted median	23	-0.0079488	0.0574376	0.8899326
Inverse variance weighted	23	-0.0295597	0.0416680	0.4780695
Simple mode	23	-0.0509185	0.0938670	0.5929593
Weighted mode	23	-0.0392470	0.0736266	0.5993399

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.73245	21	0.2589378
Inverse variance weighted	24.82107	22	0.3057076

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001689	0.006157	0.7865218

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007693	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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