Two sample MR report

Telomere_length against QC T2 FLAIR-to-T1 linear alignment discrepancy

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0571598	0.0991895	0.5705590
Weighted median	23	-0.1100827	0.0575627	0.0558253
Inverse variance weighted	23	-0.0664611	0.0387566	0.0863758
Simple mode	23	0.0504744	0.1099246	0.6506147
Weighted mode	23	-0.0665706	0.0715432	0.3622136

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.62441	21	0.6092201
Inverse variance weighted	18.63478	22	0.6677590

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000571	0.0056056	0.9198254

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006538	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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