Two sample MR report

Telomere_length against QC T1-to-standard nonlinear alignment warping

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1160544	0.0974800	0.2471166
Weighted median	23	0.0372058	0.0526082	0.4794269
Inverse variance weighted	23	0.0057359	0.0381005	0.8803329
Simple mode	23	0.0297269	0.0770938	0.7035012
Weighted mode	23	0.0420510	0.0562528	0.4626562

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.76814	21	0.8344038
Inverse variance weighted	16.27982	22	0.8017593

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067743	0.0055098	0.2324797

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000494	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8