Two sample MR report

Telomere_length against QC T1-to-standard nonlinear alignment discrepancy

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0622344	0.1281530	0.6322607
Weighted median	23	0.0098872	0.0578792	0.8643613
Inverse variance weighted	23	-0.0106381	0.0491601	0.8286779
Simple mode	23	-0.0144786	0.1064637	0.8930613
Weighted mode	23	-0.0194666	0.0754430	0.7987821

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.29586	21	0.0202494
Inverse variance weighted	36.62655	22	0.0259861

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031684	0.0072435	0.6662796

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011122	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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