Two sample MR report

Telomere_length against QC T1-to-standard linear alignment discrepancy

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0739367	0.0974795	0.4565894
Weighted median	23	0.0344046	0.0550635	0.5320908
Inverse variance weighted	23	0.0103429	0.0381004	0.7860351
Simple mode	23	-0.0486015	0.0874896	0.5841497
Weighted mode	23	0.0527021	0.0663461	0.4354767

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.53596	21	0.4875771
Inverse variance weighted	21.03830	22	0.5183721

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039051	0.0055098	0.4862658

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006397	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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