Two sample MR report

Telomere_length against QC T1 inverse SNR

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1471975	0.1176915	0.2247979
Weighted median	23	0.1020756	0.0568205	0.0724218
Inverse variance weighted	23	0.1104122	0.0450659	0.0142849
Simple mode	23	0.0802104	0.0861894	0.3621457
Weighted mode	23	0.1158517	0.0570319	0.0544730

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.61191	21	0.0803639
Inverse variance weighted	30.77999	22	0.1007061

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022589	0.0066522	0.7375533

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011872	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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