Two sample MR report

Telomere_length against QC T1 inverse CNR

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1488790	0.1098742	0.1898171
Weighted median	23	0.0863872	0.0543246	0.1117884
Inverse variance weighted	23	0.0746210	0.0424927	0.0790733
Simple mode	23	0.1415342	0.0990655	0.1671373
Weighted mode	23	0.0894492	0.0641220	0.1769461

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.68014	21	0.1816931
Inverse variance weighted	27.36509	22	0.1976870

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00456	0.0062104	0.4709135

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009455	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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