Two sample MR report

Telomere_length against QC SWI-to-T1 linear alignment discrepancy

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0604090	0.1076080	0.5804803
Weighted median	23	-0.0698532	0.0605325	0.2485094
Inverse variance weighted	23	-0.0658562	0.0410956	0.1090423
Simple mode	23	-0.1041802	0.0989923	0.3040353
Weighted mode	23	-0.0504246	0.0658584	0.4520206

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.63449	21	0.3637715
Inverse variance weighted	22.63775	22	0.4224196

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003347	0.0060853	0.9566623

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007661	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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