Two sample MR report

Telomere_length against IDP tfMRI median zstat shapes

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0889489	0.1067152	0.4139340
Weighted median	23	-0.1115609	0.0647499	0.0848977
Inverse variance weighted	23	-0.0549603	0.0417177	0.1876938
Simple mode	23	-0.0925039	0.1044800	0.3855297
Weighted mode	23	-0.1383540	0.0857690	0.1209767

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.78590	21	0.5988722
Inverse variance weighted	18.90564	22	0.6511478

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020887	0.0060361	0.7327594

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006255	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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