Two sample MR report

Telomere_length against IDP tfMRI median zstat faces-shapes amygdala

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0014621	0.1341918	0.9914093
Weighted median	23	0.0330556	0.0652310	0.6123329
Inverse variance weighted	23	-0.0004149	0.0512539	0.9935407
Simple mode	23	0.0004616	0.1246973	0.9970797
Weighted mode	23	0.0885427	0.0840919	0.3038020

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.20774	21	0.0439638
Inverse variance weighted	33.20810	22	0.0590059

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001154	0.0075903	0.9880181

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010062	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8