Two sample MR report

Telomere_length against IDP tfMRI median zstat faces-shapes

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0751244	0.1302392	0.5701940
Weighted median	23	0.0290512	0.0633289	0.6464246
Inverse variance weighted	23	-0.0376427	0.0498597	0.4502657
Simple mode	23	0.0356066	0.1220387	0.7732000
Weighted mode	23	0.0807434	0.0788583	0.3170076

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.28042	21	0.0691160
Inverse variance weighted	31.42604	22	0.0877215

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023034	0.0073667	0.7576119

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009768	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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