Two sample MR report

Telomere_length against IDP tfMRI median zstat faces

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1154218	0.1067154	0.2917013
Weighted median	23	-0.0878003	0.0609485	0.1497077
Inverse variance weighted	23	-0.0609146	0.0417178	0.1442467
Simple mode	23	-0.0767152	0.1022682	0.4611196
Weighted mode	23	-0.0940937	0.0790956	0.2468763

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.20773	21	0.8605119
Inverse variance weighted	14.51568	22	0.8821713

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033496	0.0060361	0.5848044

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005045	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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