Two sample MR report

Telomere_length against IDP tfMRI median BOLD shapes

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0612915	0.1169499	0.6057085
Weighted median	23	-0.0942835	0.0664421	0.1558896
Inverse variance weighted	23	-0.0339736	0.0447362	0.4476003
Simple mode	23	-0.0704323	0.1255171	0.5803754
Weighted mode	23	-0.1068995	0.0941914	0.2686242

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.22173	21	0.2376887
Inverse variance weighted	25.29908	22	0.2829874

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016788	0.006615	0.8021324

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007867	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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