Two sample MR report

Telomere_length against IDP tfMRI median BOLD faces-shapes amygdala

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0592952	0.1397651	0.6756986
Weighted median	23	0.0935368	0.0655296	0.1534654
Inverse variance weighted	23	0.0111021	0.0537617	0.8363957
Simple mode	23	0.0516318	0.1127609	0.6515239
Weighted mode	23	0.1243393	0.0834419	0.1503885

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.02357	21	0.0217323
Inverse variance weighted	36.53727	22	0.0265731

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0043262	0.0079055	0.5899882

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011092	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8