Two sample MR report

Telomere_length against IDP tfMRI median BOLD faces-shapes

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0543861	0.1362526	0.6938082
Weighted median	23	0.0878325	0.0628712	0.1624067
Inverse variance weighted	23	-0.0164698	0.0521541	0.7521613
Simple mode	23	-0.0161696	0.1180981	0.8923419
Weighted mode	23	0.1061344	0.0836495	0.2177735

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.23558	21	0.0341893
Inverse variance weighted	34.38460	22	0.0448729

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023301	0.0077068	0.7653671

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010465	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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