Two sample MR report

Telomere_length against IDP tfMRI median BOLD faces

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0749858	0.1067151	0.4899764
Weighted median	23	-0.0545965	0.0603128	0.3653472
Inverse variance weighted	23	-0.0409819	0.0417178	0.3259220
Simple mode	23	-0.0969898	0.1038449	0.3604495
Weighted mode	23	-0.0777547	0.0841052	0.3652592

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.95179	21	0.6520531
Inverse variance weighted	18.07164	22	0.7017327

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020896	0.0060361	0.7326438

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005769	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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