Two sample MR report

Telomere_length against IDP tfMRI 90th-percentile zstat shapes

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0566425	0.1067160	0.6011412
Weighted median	23	-0.0964875	0.0611589	0.1146454
Inverse variance weighted	23	-0.0539617	0.0417179	0.1958412
Simple mode	23	-0.0853833	0.0978888	0.3924937
Weighted mode	23	-0.0978271	0.0815576	0.2430987

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.37386	21	0.7482913
Inverse variance weighted	16.37460	22	0.7968692

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001647	0.0060361	0.9784838

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005469	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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