Two sample MR report

Telomere_length against IDP tfMRI 90th-percentile zstat faces-shapes amygdala

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1062341	0.1193297	0.3834141
Weighted median	23	0.1208336	0.0655350	0.0652117
Inverse variance weighted	23	0.0245089	0.0461745	0.5955658
Simple mode	23	0.1551871	0.1320423	0.2524448
Weighted mode	23	0.1872418	0.0957091	0.0632355

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.26045	21	0.1966917
Inverse variance weighted	26.95280	22	0.2130246

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0050224	0.0067497	0.4650706

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008272	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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