Two sample MR report

Telomere_length against IDP tfMRI 90th-percentile zstat faces-shapes

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0433155	0.1185075	0.7183873
Weighted median	23	0.0375841	0.0591472	0.5251463
Inverse variance weighted	23	-0.0156656	0.0453323	0.7296646
Simple mode	23	0.0794298	0.0979313	0.4260097
Weighted mode	23	0.0591547	0.0698495	0.4061762

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.89837	21	0.2103508
Inverse variance weighted	25.97761	22	0.2526444

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016992	0.0067031	0.8023537

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007913	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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