Two sample MR report

Telomere_length against IDP tfMRI 90th-percentile zstat faces

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0682343	0.1067156	0.5294744
Weighted median	23	-0.0220078	0.0578686	0.7037180
Inverse variance weighted	23	-0.0686225	0.0417180	0.0999878
Simple mode	23	0.0099820	0.0911359	0.9137757
Weighted mode	23	-0.0156445	0.0673325	0.8184161

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.91751	21	0.8270682
Inverse variance weighted	14.91752	22	0.8657531

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-2.39e-05	0.0060361	0.996884

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000534	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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