Two sample MR report

Telomere_length against IDP tfMRI 90th-percentile BOLD shapes

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0178164	0.1082130	0.8708006
Weighted median	23	-0.0558810	0.0624591	0.3709572
Inverse variance weighted	23	-0.0537850	0.0417176	0.1973061
Simple mode	23	0.0664048	0.1026189	0.5242618
Weighted mode	23	-0.0685720	0.0824559	0.4145587

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.59349	21	0.4232507
Inverse variance weighted	21.72758	22	0.4762459

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022104	0.0061208	0.7216136

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007088	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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