Two sample MR report

Telomere_length against IDP tfMRI 90th-percentile BOLD faces-shapes amygdala

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0878207	0.1194716	0.4704231
Weighted median	23	0.1471951	0.0621731	0.0179086
Inverse variance weighted	23	0.0473201	0.0457787	0.3012898
Simple mode	23	0.1392414	0.1105644	0.2210951
Weighted mode	23	0.1728820	0.0803644	0.0427000

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.32237	21	0.1944229
Inverse variance weighted	26.49240	22	0.2311422

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024889	0.0067577	0.7163301

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008417	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8