Two sample MR report

Telomere_length against IDP tfMRI 90th-percentile BOLD faces-shapes

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0433050	0.1232882	0.7289004
Weighted median	23	0.1312347	0.0611577	0.0318858
Inverse variance weighted	23	0.0116646	0.0471766	0.8047115
Simple mode	23	0.0930441	0.1126199	0.4175730
Weighted mode	23	0.1337197	0.0767015	0.0952283

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.03147	21	0.1392611
Inverse variance weighted	28.13524	22	0.1712423

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019444	0.0069736	0.7831049

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008549	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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