Two sample MR report

Telomere_length against IDP tfMRI 90th-percentile BOLD faces

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0122954	0.1067154	0.9093676
Weighted median	23	-0.0263109	0.0569117	0.6438581
Inverse variance weighted	23	-0.0594933	0.0417180	0.1538440
Simple mode	23	-0.0889987	0.0933144	0.3505726
Weighted mode	23	-0.0175707	0.0661117	0.7928892

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.12295	21	0.5134858
Inverse variance weighted	20.35385	22	0.5609163

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029004	0.0060361	0.6358277

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006784	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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