Two sample MR report

Telomere_length against IDP dMRI TBSS OD Uncinate fasciculus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0336202	0.1003888	0.7410229
Weighted median	23	-0.0044997	0.0578469	0.9379986
Inverse variance weighted	23	-0.0325855	0.0392330	0.4062197
Simple mode	23	-0.0901752	0.1002130	0.3779526
Weighted mode	23	-0.0220289	0.0696039	0.7546145

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.35901	21	0.6891275
Inverse variance weighted	17.35913	22	0.7432375

Test for directional horizontal pleiotropy

egger_intercept	se	pval
6.35e-05	0.0056741	0.9911719

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005469	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8