Two sample MR report

Telomere_length against IDP dMRI TBSS OD Uncinate fasciculus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1828952	0.1112082	0.1149358
Weighted median	23	-0.0644732	0.0600225	0.2827546
Inverse variance weighted	23	-0.0573452	0.0439563	0.1920310
Simple mode	23	0.0828481	0.1030276	0.4299233
Weighted mode	23	-0.0612921	0.0755086	0.4256459

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.77076	21	0.2153253
Inverse variance weighted	27.61682	22	0.1887300

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0077094	0.0062857	0.2335837

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009015	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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