Two sample MR report

Telomere_length against IDP dMRI TBSS OD Tapetum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0491876	0.1179509	0.6808979
Weighted median	23	-0.0936564	0.0620440	0.1311671
Inverse variance weighted	23	-0.0155322	0.0451396	0.7307763
Simple mode	23	-0.0758791	0.1328144	0.5735759
Weighted mode	23	-0.1238647	0.0895748	0.1805997

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.99139	21	0.1142084
Inverse variance weighted	29.12405	22	0.1413531

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020666	0.0066668	0.7596266

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008873	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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