Two sample MR report

Telomere_length against IDP dMRI TBSS OD Tapetum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0133546	0.1003892	0.8954375
Weighted median	23	0.0269971	0.0565144	0.6328622
Inverse variance weighted	23	0.0067740	0.0392331	0.8629186
Simple mode	23	0.1287905	0.0998819	0.2106416
Weighted mode	23	0.0303461	0.0663508	0.6518983

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.90589	21	0.7167951
Inverse variance weighted	16.95334	22	0.7659321

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001236	0.0056741	0.8296649

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005147	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8