Two sample MR report

Telomere_length against IDP dMRI TBSS OD Sagittal stratum R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2527848	0.1206356	0.0484319
Weighted median	23	-0.1228936	0.0573950	0.0322587
Inverse variance weighted	23	-0.1230527	0.0475350	0.0096346
Simple mode	23	-0.1674608	0.0802980	0.0488363
Weighted mode	23	-0.1451476	0.0632034	0.0315401

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.32604	21	0.0856295
Inverse variance weighted	32.29719	22	0.0724686

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0079662	0.0068185	0.2557711

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012768	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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