Two sample MR report

Telomere_length against IDP dMRI TBSS OD Sagittal stratum L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1714192	0.1195965	0.1664897
Weighted median	23	-0.1161045	0.0593135	0.0502923
Inverse variance weighted	23	-0.1309664	0.0458112	0.0042520
Simple mode	23	-0.0707569	0.1087473	0.5220080
Weighted mode	23	-0.1410146	0.0678623	0.0495887

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.80572	21	0.0959620
Inverse variance weighted	29.99738	22	0.1185281

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002484	0.0067598	0.7169475

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012466	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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