Two sample MR report

Telomere_length against IDP dMRI TBSS OD Pontine crossing tract

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0760439	0.1022946	0.4654872
Weighted median	23	0.0658852	0.0572751	0.2500083
Inverse variance weighted	23	0.0015987	0.0396356	0.9678253
Simple mode	23	0.0544825	0.0923094	0.5610596
Weighted mode	23	0.0627519	0.0668834	0.3583143

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.80473	21	0.4108368
Inverse variance weighted	22.45377	22	0.4330995

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045713	0.0057818	0.4379982

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006805	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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