Two sample MR report

Telomere_length against IDP dMRI TBSS OD Middle cerebellar peduncle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0902440	0.1049258	0.3994606
Weighted median	23	-0.0035164	0.0546574	0.9487038
Inverse variance weighted	23	0.0293116	0.0414991	0.4799891
Simple mode	23	0.0486722	0.1134049	0.6719594
Weighted mode	23	-0.0350580	0.0691956	0.6174400

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.94126	21	0.3471181
Inverse variance weighted	24.61525	22	0.3158251

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0073413	0.0059306	0.2294236

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007628	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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