Two sample MR report

Telomere_length against IDP dMRI TBSS OD Medial lemniscus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0507528	0.1039391	0.6304020
Weighted median	23	0.0979297	0.0573684	0.0878161
Inverse variance weighted	23	0.1229474	0.0402209	0.0022371
Simple mode	23	0.1101290	0.0872052	0.2198564
Weighted mode	23	0.0832309	0.0647116	0.2117517

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.51197	21	0.3705401
Inverse variance weighted	23.12238	22	0.3948467

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044331	0.0058747	0.4588698

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009982	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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