Two sample MR report

Telomere_length against IDP dMRI TBSS OD Medial lemniscus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1031308	0.1033188	0.3295554
Weighted median	23	0.0585081	0.0553381	0.2903823
Inverse variance weighted	23	0.1100501	0.0394546	0.0052825
Simple mode	23	0.0628941	0.0865648	0.4751586
Weighted mode	23	0.0701709	0.0636199	0.2819594

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.24398	21	0.3855688
Inverse variance weighted	22.24959	22	0.4450781

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004249	0.0058397	0.942688

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009126	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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