Two sample MR report

Telomere_length against IDP dMRI TBSS OD Fornix

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0359228	0.1003881	0.7240356
Weighted median	23	0.0366369	0.0558350	0.5117188
Inverse variance weighted	23	0.0143466	0.0392329	0.7146050
Simple mode	23	0.0422061	0.0859464	0.6282362
Weighted mode	23	0.0389947	0.0653870	0.5570165

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.94515	21	0.4622984
Inverse variance weighted	21.24110	22	0.5058833

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030868	0.005674	0.5921603

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006477	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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