Two sample MR report

Telomere_length against IDP dMRI TBSS OD External capsule R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0486846	0.1487021	0.7466092
Weighted median	23	0.0318647	0.0569387	0.5757311
Inverse variance weighted	23	0.0254562	0.0568167	0.6541235
Simple mode	23	0.0754187	0.0916871	0.4195815
Weighted mode	23	0.0595666	0.0575996	0.3123009

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.07695	21	0.0012481
Inverse variance weighted	46.14014	22	0.0018970

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014263	0.0084048	0.8668675

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014108	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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