Two sample MR report

Telomere_length against IDP dMRI TBSS OD External capsule L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0372406	0.1409541	0.7941983
Weighted median	23	0.0338078	0.0599804	0.5729943
Inverse variance weighted	23	0.0321694	0.0538216	0.5500366
Simple mode	23	-0.0089346	0.1031936	0.9317875
Weighted mode	23	0.0275704	0.0656725	0.6786906

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.40105	21	0.0050000
Inverse variance weighted	41.40406	22	0.0073745

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003114	0.0079669	0.969191

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012749	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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