Two sample MR report

Telomere_length against IDP dMRI TBSS OD Cingulum hippocampus R

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0762553	0.1298551	0.5633080
Weighted median	23	-0.1059848	0.0639032	0.0972127
Inverse variance weighted	23	-0.0582597	0.0496086	0.2402402
Simple mode	23	0.0621580	0.1176568	0.6025807
Weighted mode	23	-0.0873453	0.0760463	0.2630646

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.13824	21	0.0272643
Inverse variance weighted	35.17616	22	0.0371338

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001105	0.0073396	0.8817632

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011327	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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