Two sample MR report

Telomere_length against IDP dMRI TBSS OD Cingulum hippocampus L

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0805888	0.1148025	0.4904009
Weighted median	23	-0.0407583	0.0611807	0.5052867
Inverse variance weighted	23	-0.0290173	0.0449433	0.5185099
Simple mode	23	-0.0991101	0.1130705	0.3902111
Weighted mode	23	-0.0642282	0.0797543	0.4292506

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.46370	21	0.1560268
Inverse variance weighted	28.87067	22	0.1485904

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067303	0.0064888	0.3114272

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008914	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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